Devoxin Bioengineering Co., Ltd. - Bioreactors, Single-Use Bioreactors, Fermenters, and Strain Technology Services

Devoxin은 생물공정 기술 및 솔루션 분야의 글로벌 선도 기업입니다. 최첨단 합성 생물학과 지능형 공정 제어를 핵심으로, 공정과 장비를 깊이 통합하여 실험실 연구, 공정 개발부터 상업적 규모 생산에 이르는 종단 간 폐쇄 루프 서비스를 제공합니다. 저희가 제공하는 것은 정밀 발효 시스템뿐만 아니라 검증된 공정, 지능형 데이터 관리, 평생 기술 지원까지 포함됩니다. 이를 통해 유전자에서 제품에 이르는 모든 단계가 효율적이고 안정적이며 규정을 준수하도록 보장합니다.

200

성공적으로 산업화된 공정 프로젝트

100

적용되는 국가 및 지역

150

핵심 특허 및 독점 기술

저희에 대해 더 알아보세요.

핵심 기술 및 플랫폼

개념부터 상업적 규모 생산까지, 전 과정에 걸쳐 신뢰할 수 있는 종합적인 지원을 제공합니다. 이는 당사의 깊은 공정 기술 전문성, 자체 핵심 장비 제조 역량, 지능형 데이터 관리 및 제어 시스템, 그리고 세계 최고 수준의 규제 적합성을 충족하는 검증 경험에 기반합니다. 저희는 장비뿐만 아니라 확실성과 성공을 함께 제공합니다.

제품

연구 개발 및 공정 개발

파일럿 규모 테스트 및 공정 스케일업

GMP 생산 시스템

액체 조제 시스템

상류 및 하류 장비

연구 개발 및 공정 개발

1L/5L10L Off-site sterilization glass fermentation tank

Product IntroductionThe 1L/5L/10L off-site sterilization glass fermenter is specifically designed for laboratory R&D applications. Featuring high-transparency full glass construction as its core, paired with a precise transmission and temperature control system, it perfectly meets the needs of small-scale cultivation of microorganisms, insect cells, and mammalian cells. The equipment is easy to operate, and the entire experimental process is fully visible in real time, allowing for real-time observation of bacterial growth and reaction progress, with excellent data reproducibility. It is an ideal tool for strain screening, process optimization, teaching experiments, and pre-pilot R&D.

30L Stainless Steel Fermenter (30SJ / 30SA)

Product Introduction The 30L Stainless Steel Fermenter (Model: 30SJ / 30SA) is a core piece of equipment designed for the transition from laboratory R&D to pilot-scale amplification. Constructed from food-grade 316L stainless steel, it integrates the operational flexibility of small-scale devices with the operational stability of pilot-scale systems. Suitable for high-viscosity and high-oxygen-demand fermentation systems, it boasts excellent thermal conductivity and can meet the cultivation requirements of microorganisms, high-value-added strains, and other cultures. It is an ideal choice for synthetic biology research, process parameter optimization, and pilot-scale process validation. Equipped with a precision stirring system (optional top mechanical stirring or bottom magnetic stirring), the equipment ensures uniform mixing of the fermentation system and stable mass transfer efficiency. It supports integration with online pH/DO sensors and v3.1 control software, enabling real-time monitoring of process parameters and data traceability—thus guaranteeing the reliability of R&D data and the consistency of pilot-scale scaling-up. Its compact structure saves laboratory space while meeting laboratory-level cleaning and sterilization requirements. Featuring user-friendly operation and easy maintenance, it helps R&D teams efficiently advance process development.

3L/10L Mammalian Cell Glass Bioreactor

Product Introduction3L/10L Mammalian Cell Glass Bioreactor The 3L/10L Mammalian Cell Glass Bioreactor (Model: 3/10GCUC) is a laboratory-scale core device specifically designed for the culture of mammalian cells, insect cells, and plant cells. It is suitable for various process scenarios such as fed-batch culture and continuous perfusion culture. Adopting a high-borosilicate glass tank, the device offers excellent chemical stability and light transmittance, enabling real-time visualization of the entire cell culture process for convenient experimental observation and data recording. It is equipped with a dedicated low-shear impeller (either pitched blade or fixed-bed type), which minimizes damage to cell viability caused by agitation. This design perfectly meets the culture requirements of suspension cells, microcarrier-adherent cells, and sheet carrier-adherent cells. Compliant with basic cGMP requirements and relevant FDA standards, the product’s structural design adheres to sterile operation specifications for bioprocess R&D. It is widely used in vaccine preparation, recombinant protein expression, antibody process development, medium optimization, and cell therapy-related research. It serves as an ideal tool for synthetic biology research, early-stage biopharmaceutical R&D, and process optimization.

High-Performance Cell Line Screening System

High-Performance Cell Line Screening System Product Overview Breakthrough R&D Bottlenecks, Accelerate Elite Strain Discovery The High-Performance Cell Line Screening System is an "intelligent, integrated screening platform" specifically designed for synthetic biology, metabolic engineering, and biopharmaceutical R&D. It integrates "high-density micro-culture, real-time online monitoring, and AI-driven phenotypic analysis", reducing traditional strain screening cycles from weeks or even months to mere days. It dramatically enhances the efficiency and success rate of discovering "high-yield, robust, and high-performance" engineered strains. This system is your core equipment for rapidly identifying the optimal candidates from vast genetic libraries and seizing a competitive R&D advantage.

Pilot-Scale Stainless Steel Fermenter (50L-1000L)

Product Core Information module Content product name Pilot-Scale Stainless Steel Fermenter (50L-1000L) product model 50/100/200/300/500/1000SS Core positioning A key pilot-scale equipment connecting R&D and production, focusing on process scale-up verification and data portability Applicable Scenarios Microbial fermentation pilot trials, process parameter optimization, small-batch sample production, and GMP compliance pre-verification

Single-Use Pilot System (250L-2000L)

Core Positioning The single-use pilot bioreactor system focuses on the "pilot scale-up" phase of bioprocesses, bridging the gap from laboratory research to commercial production. It accommodates a process scale of 250L-2000L, balances flexibility and compliance, and assists users in efficiently completing process verification and production capacity transition.

JM-2/JM-6 tubular centrifuge

Product Introduction High-speed tubular centrifuge series, featuring high separation efficiency and stable performance, is suitable for material separation in pilot-scale and process scaling-up scenarios. It is widely used in the pharmaceutical, biological products, chemical, food and beverage industries. After equipment purchase, installation, commissioning, on-site operation guidance and training services are provided to ensure the smooth commissioning of the equipment.

50L-1000L Mammalian Cell Stainless Steel Bioreactor

The 50L-1000L mammalian cell bioreactor is a GMP-grade core equipment designed for the large-scale production of biologics such as antibodies, recombinant proteins, and viral vectors. Constructed with full 316L stainless steel wetted parts and integrated with high-precision sensors and an intelligent control system, it enables the stable regulation of key parameters during cell culture, including temperature (±0.1℃), pH (±0.05), and dissolved oxygen (±1%). The system is equipped with sterile Clean-In-Place (CIP) and Sterilize-In-Place (SIP) modules, which avoid cross-contamination throughout the entire process and meet the production requirements of Class C/D clean areas. To address the low-shear demand of mammalian cells, the bioreactor is fitted with a dedicated impeller stirring system (e.g., Marine impeller) and supports customized components such as gas spargers and defoaming devices. It is suitable for the high-density culture processes of cells like CHO and HEK293 (with a maximum cell density of up to 1×10⁷ cells/mL). The modular design allows for linkage with upstream and downstream purification systems, enabling seamless integration into production lines of 2000L and above. This makes it a reliable choice for biopharmaceutical companies transitioning from clinical to commercial production.

Pilot-Scale Mammalian Cell Bioreactor (50L-500L)

Product Introduction This pilot-scale mammalian cell bioreactor is specifically designed for cell culture process scale-up, addressing the connection needs between laboratory bench-scale trials and pilot production. It supports the high-density culture of mainstream cell lines such as CHO, VERO, and HEK293. Equipped with a modular magnetic drive system, it integrates operational safety and process precision; the advanced parameter control system can stably achieve process objectives including cell growth and protein expression, meeting the compliance requirements for biopharmaceutical R&D and pilot production.

GMP-Compliant Stainless Steel Microbial Fermenter (100L-5000L)

Product Introduction GMP-Compliant Stainless Steel Microbial Fermenter (100L-5000L) This series of fermenters are industrial-scale production systems designed for high-density microbial fermentation, fully complying with international standards such as GMP and ASME BPE. They are suitable for commercial production in the pharmaceutical, food, and biochemical industries. Constructed with 316L stainless steel, the tank’s inner surface features a polishing precision of Ra≤0.4μm. Combined with in-situ sterilization (SIP) and clean-in-place (CIP) functions, it enables full-process control of aseptic production. Equipped with a PLC automatic control system, it can real-time monitor key parameters such as temperature, pH, and dissolved oxygen, supporting multiple process modes (batch/fed-batch/continuous culture) to facilitate seamless scale-up from laboratory trials to large-scale production.

Vaccine-Specific GMP Production System for Human Vaccines

Product OverviewThe Vaccine-Specific GMP Production System is a specialized bioreactor and supporting process system developed for the production processes of vaccines such as Pertussis, HPV, and COVID-19 vaccines. It fully meets the high compliance, high precision, and high automation requirements of human vaccine production. The system design complies with GMP and EU-related standards and is adaptable to the large-scale production of different vaccine technology routes.

GMP Production System - Liquid Preparation System

Product Introduction The GMP-grade Liquid Preparation System is a core supporting unit in the full biopharmaceutical production process, providing stable and compliant liquid preparation support specifically for biological culture, separation and purification, and vaccine inactivation/activation processes, spanning the entire biopharmaceutical production chain. Designed with GMP-compliant concepts and material selection, the system adapts to scenarios from laboratory R&D to large-scale production, ensuring the precision, sterility, and traceability of processes, and serving as a key equipment for biopharmaceutical enterprises to achieve standardized and efficient production.

5000L-100KL Microorganism Series Large-Scale Fermentation System

Product Introduction 5000L-100KL Microorganism Series Large-Scale Fermentation System is core equipment designed for industrial-scale biomanufacturing. It is fully compatible with large-scale production needs in multiple fields, including antibiotics, enzymes, amino acids, probiotics, bioenergy, and biochemicals. Based on DevoTion's mature technical accumulation in bioreactors, the system takes "precision control, high efficiency and stability, energy conservation and consumption reduction, and easy expansion" as its core advantages, realizing seamless connection from laboratory processes to industrial production and providing reliable large-scale fermentation solutions for global biomanufacturing enterprises. Adopting a modular design concept, the system can flexibly configure functional units such as stirring, aeration, temperature control, feeding, and sterilization according to the characteristics of different microbial strains (aerobic/facultative anaerobic) and process requirements, balancing process adaptability and operational convenience. The core control system integrates real-time multi-parameter monitoring and intelligent regulation functions, ensuring the precise and stable control of key parameters such as temperature, pH value, dissolved oxygen (DO), stirring speed, and aeration rate during fermentation to maximize microbial metabolic efficiency and target product yield. Meanwhile, the system strictly complies with industrial production compliance requirements, with material selection and structural design meeting the hygiene standards of the biomanufacturing industry, supporting in-situ sterilization (SIP) and clean-in-place (CIP) to effectively reduce pollution risks and ensure production continuity and consistent product quality.

3000L-5000L industrial bioreactor

Product Introduction The 3000L-5000L Industrial Bioreactor is a core production equipment designed for microbial fermentation and large-scale cell culture. It caters to the industrial production needs of various fields such as biopharmaceuticals, vaccines, biological products, and industrial enzymes. Constructed with an all-stainless steel structure, the equipment is equipped with a precise control system and in-situ sterilization (SIP) function. It can achieve high-density culture and high product expression, meet GMP production standards, and provide customers with stable, efficient, and scalable biomanufacturing solutions.

Industrial Production Line for Astaxanthin/DHA/ARA Synthetic Biology

Product Introduction The Astaxanthin/DHA/ARA Synthetic Biology Industrial Production Line is a fully integrated solution designed for synthetic biology applications, covering the entire process from strain cultivation, fermentation control to downstream separation and purification. The production line features a cluster of stainless steel bioreactors and automated control systems, enabling high-density fermentation, precise parameter regulation, and continuous production, thus significantly improving the yield and purity of target metabolites. Tailored to the characteristics of lipophilic metabolites such as astaxanthin, DHA, and ARA, the line is equipped with efficient in-situ product extraction, membrane separation, and refining units, which effectively reduce downstream separation costs and ensure consistent product quality. From lab-scale trials to 10,000-ton industrial production, Divosyn provides turnkey engineering solutions with seamless scalability, meeting the full-cycle needs of synthetic biology enterprises from R&D to large-scale manufacturing.

The complete process of design, installation, and qualification

Product Introduction Divoxin provides EPC (Engineering, Procurement, Construction) turnkey services covering the entire industrial chain of bioreactors. We deliver integrated solutions from conceptual design to validation for customers in synthetic biology, biopharmaceuticals, and biomanufacturing, ensuring seamless execution throughout the entire lifecycle: design, procurement, manufacturing, installation, and qualification.

Online pH/DO sensor

Online Process Analytical Sensors The system integrates high-stability online sensors for real-time monitoring and data acquisition of critical parameters (such as pH, dissolved oxygen, temperature, viable cell density, and key metabolite concentrations) during bioprocessing. The sensors feature long-term operational stability and anti-fouling design, delivering accurate signal output to provide real-time data input for process control and optimization.

v3.1 control software

Distributed Control System & Data Acquisition SystemThe system employs a Distributed Control System based on industrial standard protocols, centered on Programmable Logic Controllers and SCADA software. This platform executes automated logic control, sequential control, and PID regulation of the bioprocess, while enabling real-time data acquisition, archiving, trend analysis, and alarm management for the entire process. The system supports electronic batch record generation and data integrity management compliant with regulatory requirements.

1L/5L10L Off-site sterilization glass fermentation tank

30L Stainless Steel Fermenter (30SJ / 30SA)

3L/10L Mammalian Cell Glass Bioreactor

High-Performance Cell Line Screening System

해결책

균주 및 공정 개발

지능형 균주 설계 + 고효율 공정 최적화합성생물학과 AI 기반 고속 스크리닝 플랫폼을 활용하여 고성능 균주를 신속하게 구축하고, 동시에 적합한 발효 및 후공정 공정을 개발합니다. 이 방식은 연구개발 주기를 단축하고 제품 성공률을 높입니다.

공정 스케일업 및 기술 이전

실험실에서 생산까지의 원활한 전환탄탄한 공정 스케일업 및 기술 이전 시스템을 통해 소규모 시험, 파일럿 생산에서 대규모 양산까지 부드럽게 전환합니다. 이를 통해 공정 일관성과 제품 안정성을 유지하고 산업화 리스크를 줄입니다.

연속 생산 및 스마트 제조

지능형 제어 + 연속 흐름 생산바이오리액터부터 후공정까지 전 과정 연속·지능형 생산 솔루션을 제공합니다. 실시간 데이터 모니터링과 AI 기반 최적화를 융합하여 고효율, 에너지 절감 및 규정 준수가 갖춰진 대규모 생산을 실현합니다.

뉴스 및 회사 발표

February 7,2026

중국 바이오의약 시대의 후반전: 다운스트림 공정 혁신 가속화, 국내 플레이어 부상

중국 바이오의약 산업은 '상업화 효율'을 핵심으로 하는 '후반전'에 진입했으며, 다운스트림 정제 공정이 핵심 경쟁 요소가 되었습니다. 전통적인 배치 공정은 효율이 낮고 비용이 높습니다. 의료비 통제 압박과 해외 경쟁 속에서 업계는 '연속 바이오 공정'과 '공정 집약화'를 통해 비용을 절감하고 효율을 높이는 것이 시급합니다. 수입 핵심(장비/소모품)에 의존하는 병목을 돌파하기 위해…

March 16,2026

글로벌 바이오리액터 시장은 기술 기반의 새로운 시대에 진입하고 있다: 2025-2029년에 대한 인사이트 및 전략적 전망.

정밀한 스테인리스 탱크 내부에서 세포 배양액이 지능형 제어 하에 순환하고, 스크린에는 실시간 데이터가 깜박인다. 이는 수십억 달러 규모 시장의 축소판이다. 2024년 글로벌 바이오리액터 시장은 70억 7,910만 달러에 달했으며, 2029년까지 100억 8,320만 달러를 돌파할 것으로 전망된다.

January 11,2026

상류 바이오의약품 제조의 새로운 시대: 연속, 지능형 및 모달 혁신의 최전선 융합

본 문서는 상류 바이오공정의 최첨단 동향과 전략을 검토한다. 회분식 생산에서 연속 제조로의 전환과 AI, 머신러닝 및 자동화가 공정 지능화를 어떻게 주도하는지 논의한다. 또한 세포 및 유전자 치료의 새로운 수요와 녹색 바이오제조의 전망을 다루며, 상류 바이오공정에서 다가올 패러다임 전환을 개괄한다.

FAQ

Q1: How does Devoxin ensure the coordination and optimization between upstream fermentation and downstream purification processes?

We adopt a design philosophy of process prioritization and system integration. During the process development phase, we utilize a digital twin platform to simulate the overall material flow and key parameters across upstream and downstream processes, ensuring efficient matching between bioreactor output and downstream capture and purification steps. All core equipment shares the same control system, enabling data connectivity and closed-loop process optimization.

Q2: Does the system comply with international pharmaceutical production regulations (e.g., FDA, EMA)?

Yes. Our hardware and software platforms strictly adhere to cGMP, FDA 21 CFR Part 11, and EU GMP Annex 11 standards. We provide a complete Validation Support Documentation Package (VSR), including templates for Design Qualification (DQ), Installation/Operational/Performance Qualification (IQ/OQ/PQ), assisting clients in passing global regulatory reviews.

Q3: We have a novel biomolecule (e.g., enzyme, vaccine, cell therapy vector) requiring industrialization. Can you provide comprehensive development support from strain to process?

Yes. This is our core service—an integrated "from gene to product" solution. We have a synthetic biology team and a process development platform that can offer full-chain collaboration, from strain construction, screening, process development, scale-up, to factory design, delivering a pilot-verified complete process package.

Q4: Does the system support continuous bioprocessing?

Yes. We provide integrated solutions ranging from continuous perfusion fermentation, continuous harvesting, to continuous downstream purification (e.g., continuous chromatography, tangential flow filtration). Our intelligent control system enables steady-state operation, real-time monitoring, and automatic adjustments, significantly improving productivity and reducing facility footprint.

Q5: How does Devoxin ensure process data integrity and support digital transformation?

Our platform incorporates built-in data integrity management (following the ALCOA+ principles), supporting electronic signatures, audit trails, and role-based access controls. Additionally, the platform features Industrial Internet of Things (IIoT) interfaces for integration with your MES/ERP systems. It also provides process data analysis, digital twin simulation, and AI optimization modules, truly enabling data-driven smart production.

Q6: For overseas projects, can you provide localized installation, training, and technical support?

Yes. We have technical service centers and partner networks in Europe, North America, and Asia, offering remote commissioning guidance, on-site installation validation, operator training, and year-round technical support. We also provide multilingual documentation and compliance files to ensure the smooth delivery and long-term stable operation of global projects.